Drug Metabolism Enzymes

Posted by : Unknown Monday 15 September 2014

Drug-metabolizing enzymes are also known as mixed-function oxidizeand containing many enzymes involvingvarious types of cytochrome and alternative components. Another form of cytochrome is a multi-gene family of enzymes that performs a critical part in the metabolism of multiple drugs and xenobiotics with each cytochrome isozymes responding differently to various chemicals in terms of its induction and inhibition. A type of cytochrome activates a variety of bladder carcinogens, for example aromatic amines and amides. Also, some forms of cytochrome activate the naturally occurring carcinogens and N-nitrosamines respectively into highly carcinogenic agents.

The carcinogenic potency, and other carcinogens and the expanse of binding of their ultimate metabolites to DNA and proteins are correlated with the induction of few cytochrome isozymes. Phase II drug-metabolizing diverse enzymes inactivate chemical carcinogens into less toxic or inactive metabolites. Several drugs change the rate of activation of carcinogens by changing the activities of phases I and II drug-metabolizing enzymes.

The balance of activation reactions relies on the chemical structure of the agents, and is subjected to various variables that are a concern of this body, or genetic background, sex, endocrine status, age, diet, and the existence of various chemicals. It is significant to perceive that the enzymes comprise in carcinogen metabolism are also involved in the drug metabolism enzymes of a variety of substrates, and thus the foreword of specific xenobiotics may change the operating level and the existence of other chemicals.

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