Wednesday, 6 August 2014
Genetic
Disorder In the central nervous system, cholinergic and dopaminergic (DA)
neurons are among the cells most susceptible to the deleterious properties of
age. Thus, the basal forebrain cholinergic organization is known to undergo
moderate neurodegenerative changes during normal aging as well as severe
atrophy in Alzheimer’s disease (AD). Parkinson's disease (PD), a degeneration
of nigro-striatal DA neurons is the most conspicuous reflection of the
vulnerability of DA neurons to age.
General there is increasing evidence that a
progressive decline in cognitive function and central DA activity represents
basic features of normal aging both in humans and research laboratory rodents. Impulsive
or conservational neurotoxin-mediated exacerbation of these processes
contributes to the symptoms of AD and PD, respectively. In this context,
neurotropic factors that can prevent or delay the decline in cognitive function
and central DA activity are of clinical interest. Among them, Disorder
Insulin-like Growth Factor I and Glial cell line-Derived Neurotropic Factor are
emerging as powerful neuro protective molecules.
This Genetic disorder article
discusses the experimental evidence supporting the neuro protective relevance
of these and related factors in the aging brain. The accessibility of encouraged
pluripotent stem cells offers a new promise for the treatment of pathologies
associated with the loss of specific cell types as for instance, Negril DA
neurons (in PD) or basal forebrain cholinergic neurons (BFCN) in the early
stages of AD. Latest studies documenting the use of cell reprogramming for the
generation of multi potent neuronal precursors as well as functional BFCN and
DA neurons are reviewed.
For Details Please Click: For a complete list, click on Bentham Science Publishers’ Journals Impacting Science
