Monday, 28 July 2014
Liver is an organ that performs multiple functions in a
human body. Manufacturing blood protein to facilitate clotting, storage of glucose
in the form of glycogen, detoxification of blood, breaking saturated fats into
cholesterol etc., are all the functions that fall in this profile.
In early stages, liver cirrhosis begins by the development of scar tissues that may be due to obesity or alcohol abuse or chronic liver diseaselike hepatitis A, B and C. Scarred tissues become an obstruction in the blood flow to liver. The obstruction of scars allows a very slow passage of blood that delays the functions of liver and alters its efficacy as per body’s requirement.
In early stages, liver cirrhosis begins by the development of scar tissues that may be due to obesity or alcohol abuse or chronic liver diseaselike hepatitis A, B and C. Scarred tissues become an obstruction in the blood flow to liver. The obstruction of scars allows a very slow passage of blood that delays the functions of liver and alters its efficacy as per body’s requirement.
Along with other liver functions cirrhosis affects drug metabolism
extensively. Since the healthy liver tissues are destroyed in cirrhosis,
cytochrome p450 (enzyme that catalyzes metabolism of organic substances) and
other enzymes responsible for drug metabolism are also altered, thus the
enzymatic activity becomes variant.This online article“The Effect of Liver Cirrhosis on the Regulation and Expression of drug metabolism enzymes”has many
interesting facts about drug metabolizing enzymes such as CYP1A, CYP3A, CYP2A
etc.
There is not one confirmed source for cessation of liver
into cirrhosis gradually. Besides the ones mentioned above, infectious diseases
are said to have a direct proportionality with cirrhosis. Liver scaring alters
production of cytokines and vascular responses. The article “The Molecular
Basis of Susceptibility to Infection in Liver Cirrhosis”also notified that
cellular immunity suffers an intense disruption due to
the progression in liver diseases with essential details.
The above research articles were published by Bentham
Science Publishers. They are a research publication company
who offer many details on liver and associated studies. They have a variety of articles
published that share maximum details with sheer authenticity on the minimized
liver function due to cirrhosis and associated complications.It publishes 130 online and print journals,
150 + open access journals, and related print/online book series. Also, they feature reviews in-depth of the original
articles along with relevant pre-clinical trials to facilitate broad learning.
For a complete list, click on Bentham Science Publishers’ Journals Impacting Science
